|[List of appearances]|
Dr. Curtis Connors was one of S.H.I.E.L.D.'s top scientists. During Green Goblin's attack on the Helicarrier, Connors lost his right arm. When Spider-Man brought him some animal DNA samples Connors assumed that they could regenerate limbs. When he tried a lizard serum on himself, he found out that he was right and he gained super strength. He took more, but he mutated into a lizard-man and began to go insane. Spidey and Doc Ock temporarily teamed up to fight him. Spider-Man and Lizard got back to Connor's lab and the rest of Spider-Man's team came. While Spidey's team (Iron Fist, Power Man, Nova and White Tiger) fought Lizard, Spider Man created a cure for the serum, which turned Lizard back into Dr. Connors. He was later captured by Doc Ock and had an electricity emitter planted on his neck, which turned him into Lizard and a member of the Sinister Six. (which also consisted of Rhino, Beetle, Kraven the Hunter and Electro.) Unlike the other members, Lizard got away, but Spider-Man promised to save him and change him back. The player(s) must fight him as a boss on the "Reptilian Ruckus" bonus level of LEGO Marvel Super Heroes.
The Lizard is a big-fig such as Colossus and Juggernaut. He is based somewhat on his appearance in the 1990s Spider-Man TV series. He wears a white lab coat over purple pants and a black shirt. In addition he is covered in green scales, has a tail, and a head similar to the Raptors from Dino.